Lipids Online News
- May 15, 2008
- Combination of multiple biomarkers predicts cardiovascular death risk
- The use of multiple biomarkers of renal and cardiovascular abnormalities improves the risk stratification of patients for death from cardiovascular disease, researchers suggest. [N Engl J Med 2008; 358: 2107-2116.]
- Hyperlipidemia increases retinal vein occlusion risk
- A systematic review of the literature shows hyperlipidemia, hypertension, and diabetes mellitus are significant risk factors for retinal vein occlusion. [Arch Ophthalmol 2008; 126: 692-699]
- Elevated fasting glucose and hypertension predict mortality in older adults
- The metabolic syndrome is linked to mortality in older adults, but only when elevated fasting glucose or hypertension are present as diagnostic components, show results from the Cardiovascular Health Study. [Arch Intern Med 2008; 168: 969-978]
- Secondary CVD events in CHD patients are not linked to adiponectin
- Total and high-molecular-weight adiponectin are not associated with risk for secondary cardiovascular disease events in patients with coronary heart disease, report investigators in the European Heart Journal. [Eur Heart J 2008; Advance online publication]
- May 14, 2008
- Heavy drinking linked to the metabolic syndrome
- Heavy drinking is associated with an increased risk for the metabolic syndrome, particularly among liquor drinkers, report researchers in The American Journal of Clinical Nutrition. [Am J Clin Nutr 2008; 87: 1455-1463]
- Increased vitamin C intake linked to reduced carotid IMT in elderly men
- Increased intake of foods containing vitamin C over a 3-year period reduces progression of carotid intima-media thickness in elderly men, report investigators.
[Nutr Metab Cardiovasc Dis 2008; Advance online publication]
- Severity of acute kidney injury after AMI predicts mortality
- The greater the severity of acute kidney injury after acute myocardial infarction the more likely patients are to die, research shows. [Lancet 2008; Advance online publication]
- May 13, 2008
- Ethnic differences in nocturnal BP and HR patterns found
- Black individuals have a higher night time blood pressure and heart rate than non-Blacks, despite having similar levels of daytime BP and HR, 24-hour BP, and baseline office BP, US study findings indicate. [Arch Intern Med 2008; 168: 996-1002]
- Adipocyte number remains constant in adulthood
- Adipocyte number can increase in childhood and adolescence but reaches a maximum in early adulthood that remains constant regardless of weight loss or gain, report investigators in the journal Nature. [Nature 2008; Advance online publication]
- Adiponectin link to inflammation, metabolic syndrome independent of obesity
- Adiponectin levels are associated with inflammatory markers, insulin resistance, and presence of the metabolic syndrome independent of the presence of obesity, show study results.
[Int J Obes 2008; 32: 772-779]
- n3 fatty acid phospholipid supplementation improved attention in ADHD children
- Phospholipids conjugated with eicosapentaenoic acid and docosahexaenoic acid and fish oil improve attention in children with attention deficit hyperactivity disorder, results of a dietary intervention study show. [Am J Clin Nutr 2008; 87: 1170-1180]
- May 9, 2008
- Cardiometabolic risk higher in male than female adolescents
- Study results show 19-year-old males have higher insulin resistance and triglyceride levels and lower levels of high-density lipoprotein cholesterol than females of the same age, despite having lower levels of body fat. [Circulation 2008; 117: 2361-2368]
- Small dense LDL most susceptible to glycation
- As well as its higher propensity to oxidation, small dense low-density lipoprotein carries the largest percentage of glycated apolipoprotein B compared with other lipid subfractions, report investigators. [Atherosclerosis 2008; Advance online publication]
- IL1RN variants are associated with high levels CRP, fibrinogen and IL-6
- The minor alleles of two IL-1 receptor antagonist gene polymorphisms are associated with elevated circulating levels of the inflammatory markers C-reactive protein, fibrinogen, and interleukin -6, show study results. [Arterioscler Thromb Vasc Biol 2008; Advance Online Publication]
- Carotid bruits predict MI, cardiovascular death
- Patients with a carotid bruit are at increased risk for myocardial infarction and cardiovascular death, meta-analysis results indicate. [Lancet 2008; 371: 1587-1594]
- May 8, 2008
- Serum visfatin reduced after weight loss in obese individuals
- A significant reduction in serum visfatin levels was observed in a group of obese individuals following a 3-month weight loss program, report investigators in the journal Nutrition. [Nutrition 2008; 24: 517-521]
- n3 PUFA intake inversely associates with CRP in young Japanese women
- Dietary intake of n3 polyunsaturated fatty acids is inversely associated with serum C-reactive protein levels in young Japanese women, report researchers. [Nutr Res 2008; 28: 309-314]
- MC4R variants linked to obesity, waist circumference, insulin resistance
- Genome-wide association data from two studies published in Nature Genetics show that several single nucleotide polymorphisms located near the melanocortin-4 receptor are associated with obesity risk, insulin resistance, and waist circumference. [Nat Genet 2008; Advance online publication]
- May 7, 2008
- Longer menstrual cycle associated with unfavorable lipid profile
- An increased length of menstrual cycle is associated with elevated levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol and low levels of high-density lipoprotein cholesterol, report investigators from the Progetto ATENA study. [Nutr Metab Cardiovasc Dis 2008; Advance online publication]
- Oxidized LDL-induced aldose reductase activity increased during foam cell formation
- Increased expression of aldose reductase caused by oxidized low-density lipoprotein during formation of foam cells, as well as increased expression and activity of AR under hyperglycemic conditions, indicates an association with atherosclerosis and diabetes, report investigators. [Arterioscler Thromb Vasc Biol 2008; Advance online publication]
- High intra-abdominal fat in adolescence increases cardiometabolic risk
- Adolescents with high intra-abdominal fat have a higher homeostasis model assessment index, higher levels of triglycerides and C-reactive protein, and lower levels of high-density lipoprotein cholesterol than those with low intra-abdominal fat, show study results. [Arch Pediatr Adolesc Med 2008; 162: 453-461]
- B vitamins fail to reduce CVD in high-risk women
- A dietary supplement combining folic acid, vitamin B6, and vitamin B12 failed to reduce the risk for cardiovascular events among women at risk for or with a history of cardiovascular disease, randomized trial data show.
[JAMA 2008; 299: 2027-2036]
- Research highlights gender differences in heart disease
- International study findings highlight key differences between women and men presenting with acute coronary syndromes. [Heart 2008; Advance online publication]
- Smoking cessation rapidly reduces vascular mortality risk in women
- Women who smoke have an increased risk for vascular mortality, but this is eliminated once they give up, say US researchers. [JAMA 2008; 299: 2037-2047]
- May 6, 2008
- Single oxidative stress biomarkers give incomplete picture
- Six "well-accepted" biomarkers of oxidative stress show variable responses to statin treatment in patients with hypercholesterolemia, say US researchers. [J Am Coll Cardiol 2008; 51: 1653-1662]
- Cholesterol monitoring may be more frequent than necessary in CHD patients
- Cholesterol monitoring soon after the initial response of patients to statin treatment is likely to detect mainly false-positive results and only becomes reliable after about 3 years, report investigators. [Ann Intern Med 2008; 148: 656-661]
- ESR1 polymorphisms influence lipid levels in women and children
- Three single nucleotide polymorphisms in the estrogen receptor 1 gene influence apolipoprotein A-I, apoA-II, and high-density lipoprotein cholesterol levels in women, as well as apoC-II and triglyceride levels in children, show study results. [J Lipid Res 2008; Advance online publication]
- Autonomic function altered with family history of hypertension, prehypertension
- Epidemiologic study findings reveal that alterations in cardiac autonomic function are already present in normotensive individuals with a family history of hypertension and those with prehypertension. [J Am Coll Cardiol 2008; 51: 1896-1901]
- Mechanisms linking depression to heart disease investigated
- Depression increases the risk for coronary heart disease in patients without heart disease through autonomic dysregulation, inflammation, and endothelial dysfunction, say Italian researchers. [Eur Heart J 2008; 29: 1110-1117]
- May 2, 2008
- Subclinical increasing thyrotropin levels raise CHD death risk
- Rising thyrotropin levels within the normal range are tied to increasing coronary heart disease mortality in women, a Norwegian population-based study reveals. [Arch Intern Med 2008; 168: 855-860]
- Baseline inflammatory markers do not influence lipids after weight loss
- Baseline levels of inflammatory markers do not influence lipid and insulin response to weight loss, report investigators in the journal Metabolism: Clinical and Experimental. [Metabolism 2008; 57: 598-604.]
- IL-6 genetic variant predisposes carriers to dyslipidemia
- The minor allele of an interleukin-6 gene single nucleotide polymorphism causes high plasma IL-6 concentrations in carriers, as well as elevated concentrations of potentially harmful lipids, report investigators. [J Lipid Res 2008; Advance online publication]
- Metabolic syndrome associated with high levels of inflammatory factors
- The presence of the metabolic syndrome and high levels of insulin resistance are linked to high levels of systemic and vascular inflammatory markers, study results indicate. [Atherosclerosis 2008; Advance online publication]
- Hypertension-related disease burden highest in developing countries
- Study findings reveal the huge burden of hypertension-related deaths worldwide is largely borne by low- and middle-income countries. [Lancet 2008; 371: 1513-1518]
- May 1, 2008
- Men bear greater atheroma burden than women
- Men with early coronary artery disease have more severe structural and functional abnormalities in their coronary arteries than women do, report researchers. [Eur Heart J 2008; Advance online publication]
- Unrelated comorbidity may compromise hypertension management
- Clinicians may be less likely to intensify treatment for uncontrolled hypertension if patients have multiple unrelated conditions, a study of more than 70,000 primary care visits has revealed. [Ann Intern Med 2008; 148: 578-586]
- Promising preliminary results from pediatric weight management program
- A multidisciplinary pediatric weight management program in the USA significantly improved the lipid profiles and slightly improved the weight status of participants, report investigators. [Obesity 2008; Advance online publication]
- APOA5 gene variant strongly associated with hypertriglyceridemia in Asians
- The minor allele of a single nucleotide polymorphism in the apolipoprotein A-V gene is linked to high levels of plasma triglycerides in Asian populations, study findings indicate. [J Lipid Res 2008; Advance online publication]
|
